Hari Prasad T P N, Shetty N J
Centre for Applied Genetics, Jnanabharathi Campus, Bangalore University, Bangalore.
J Commun Dis. 2007 Sep;39(3):147-51.
Anopheles stephensi is an important urban malaria vector, which is widely distributed throughout the Indian subcontinent. The said vector species has developed resistance to various insecticides and therefore, it is desirable to develop alternative strategies including genetic methods for its control. One of the requirements for such strategy is to establish morphological mutants and to establish the genetic basis of the same. Such mutant markers could be used in the construction of genetically modified strain/s in the genetic control programme of An. stephensi. The dark colour expresses in all larval stages and pupae with full penetarence and uniform expression in both the sexes. The viability of the mutant is as good as the wild type. The genetic studies of the dark larva revealed that the gene da is mono-factorial, autosomal and recessive to the wild type. The gene da is an excellent marker for An. stephensi.
斯氏按蚊是一种重要的城市疟疾传播媒介，广泛分布于整个印度次大陆。上述媒介物种已对多种杀虫剂产生抗性，因此，需要制定包括遗传方法在内的替代策略来对其进行控制。这种策略的要求之一是建立形态突变体并确定其遗传基础。此类突变标记可用于斯氏按蚊遗传控制计划中基因改造品系的构建。深色在所有幼虫阶段和蛹期均有表达，具有完全的外显率，且在两性中表达一致。突变体的生存能力与野生型相当。对深色幼虫的遗传研究表明，基因da是单因子的、常染色体的，且对野生型呈隐性。基因da是斯氏按蚊的一个优良标记。
