Sun M K, Spyer K M
Department of Physiology, Royal Free Hospital School of Medicine, London, U.K.
J Auton Nerv Syst. 1991 Apr;33(1):85-9. doi: 10.1016/0165-1838(91)90021-t.
The pattern of discharge of rostroventrolateral 'vasomotor' neurones has been studied in the decerebrate rat before and following the administration of pentobarbitone. Baroreflex inputs were effective in both situations, but the sensitivity of the reflex was heightened in the anaesthetised decerebrate condition even though the anaesthetic depressed neuronal discharge. The application of this anaesthetic failed to depress the inhibitory action of iontophoretically applied gamma-aminobutyric acid whose effectiveness was, if anything, enhanced. Arterial blood pressure was also reduced on the administration of the anaesthetic. These observations, taken together, suggest that the action of this, and potentially other anaesthetic agents, in lowering blood pressure may be mediated, in part, by the lowering of activity of these rostroventrolateral 'vasomotor' neurones.
在给戊巴比妥前后，对去大脑大鼠延髓头端腹外侧“血管运动”神经元的放电模式进行了研究。在两种情况下，压力感受性反射输入均有效，但尽管麻醉剂会抑制神经元放电，但在麻醉的去大脑状态下，反射的敏感性仍会增强。这种麻醉剂的应用未能抑制离子电渗法施加的γ-氨基丁酸的抑制作用，而γ-氨基丁酸的有效性甚至有所增强。给予麻醉剂后动脉血压也会降低。综合这些观察结果表明，这种以及其他潜在麻醉剂降低血压的作用可能部分是通过降低这些延髓头端腹外侧“血管运动”神经元的活动来介导的。
