Hacking hexokinase halts tumor growth.
作者信息
Fan Yongjun, Zong Wei-Xing
机构信息
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794, USA.
出版信息
Cancer Biol Ther. 2008 Jul;7(7):1136-8. doi: 10.4161/cbt.7.7.6536. Epub 2008 Jun 30.
Abstract
摘要
相似文献
1
Hacking hexokinase halts tumor growth.破坏己糖激酶可阻止肿瘤生长。
Cancer Biol Ther. 2008 Jul;7(7):1136-8. doi: 10.4161/cbt.7.7.6536. Epub 2008 Jun 30.
2
Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo.己糖激酶II基因的稳定RNA干扰在体外和体内均抑制人结肠癌LoVo细胞的生长。
Cancer Biol Ther. 2008 Jul;7(7):1128-35. doi: 10.4161/cbt.7.7.6199. Epub 2008 Apr 28.
3
Silencing hexokinase II gene sensitizes human colon cancer cells to 5-fluorouracil.沉默己糖激酶II基因可使人结肠癌细胞对5-氟尿嘧啶敏感。
Hepatogastroenterology. 2009 Mar-Apr;56(90):355-60.
4
Downregulation of the hexokinase II gene sensitizes human colon cancer cells to 5-fluorouracil.己糖激酶II基因的下调使人类结肠癌细胞对5-氟尿嘧啶敏感。
Chemotherapy. 2008;54(5):357-63. doi: 10.1159/000153655. Epub 2008 Sep 5.
5
Metastatic cancer cells compensate for low energy supplies in hostile microenvironments with bioenergetic adaptation and metabolic reprogramming.转移性癌细胞通过生物能量适应和代谢重编程来弥补恶劣微环境中的低能量供应。
Int J Oncol. 2018 Dec;53(6):2590-2604. doi: 10.3892/ijo.2018.4582. Epub 2018 Oct 2.
6
CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression.环状 RNA CDKN2B-AS1 与 IMP3 相互作用稳定己糖激酶 2 mRNA，促进宫颈鳞状细胞癌细胞有氧糖酵解进展。
J Exp Clin Cancer Res. 2020 Dec 11;39(1):281. doi: 10.1186/s13046-020-01793-7.
7
Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells.白细胞介素-22通过靶向人结肠癌细胞中的己糖激酶-2促进与肿瘤进展相关的有氧糖酵解。
Oncotarget. 2017 Apr 11;8(15):25372-25383. doi: 10.18632/oncotarget.15913.
8
Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2.白杨素通过靶向己糖激酶-2抑制肝癌细胞的糖酵解并诱导其凋亡。
J Exp Clin Cancer Res. 2017 Mar 20;36(1):44. doi: 10.1186/s13046-017-0514-4.
9
HSPE1 enhances aerobic glycolysis to promote progression of lung adenocarcinoma.HSPE1 增强有氧糖酵解以促进肺腺癌的进展。
Mutat Res. 2024 Jul-Dec;829:111867. doi: 10.1016/j.mrfmmm.2024.111867. Epub 2024 Jun 8.
10
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.苄丝肼是一种多巴脱羧酶抑制剂，通过靶向己糖激酶2来抑制肿瘤生长。
J Exp Clin Cancer Res. 2017 Apr 20;36(1):58. doi: 10.1186/s13046-017-0530-4.
引用本文的文献
1
Novel predictive biomarkers for cervical cancer prognosis.宫颈癌预后的新型预测生物标志物。
Mol Clin Oncol. 2016 Dec;5(6):792-796. doi: 10.3892/mco.2016.1055. Epub 2016 Oct 19.
2
Emerging glycolysis targeting and drug discovery from chinese medicine in cancer therapy.在癌症治疗中，从中医药到新兴的糖酵解靶向和药物发现。
Evid Based Complement Alternat Med. 2012;2012:873175. doi: 10.1155/2012/873175. Epub 2012 Jul 12.
本文引用的文献
1
Tumor cell metabolism: cancer's Achilles' heel.肿瘤细胞代谢：癌症的致命弱点。
Cancer Cell. 2008 Jun;13(6):472-82. doi: 10.1016/j.ccr.2008.05.005.
2
Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo.己糖激酶II基因的稳定RNA干扰在体外和体内均抑制人结肠癌LoVo细胞的生长。
Cancer Biol Ther. 2008 Jul;7(7):1128-35. doi: 10.4161/cbt.7.7.6199. Epub 2008 Apr 28.
3
Methyl jasmonate binds to and detaches mitochondria-bound hexokinase.茉莉酸甲酯与结合在线粒体上的己糖激酶结合并使其分离。
Oncogene. 2008 Aug 7;27(34):4636-43. doi: 10.1038/onc.2008.108. Epub 2008 Apr 14.
4
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.小分子抑制6-磷酸果糖-2-激酶活性可抑制糖酵解通量和肿瘤生长。
Mol Cancer Ther. 2008 Jan;7(1):110-20. doi: 10.1158/1535-7163.MCT-07-0482.
5
Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinases I and II.己糖激酶I和II的保护作用需要葡萄糖磷酸化和线粒体结合。
Mol Cell Biol. 2008 Feb;28(3):1007-17. doi: 10.1128/MCB.00224-07. Epub 2007 Nov 26.
6
Glucose-dependent active ATP depletion by koningic acid kills high-glycolytic cells.麦角硫因通过葡萄糖依赖性的主动ATP消耗杀死高糖酵解细胞。
Biochem Biophys Res Commun. 2008 Jan 11;365(2):362-8. doi: 10.1016/j.bbrc.2007.10.199. Epub 2007 Nov 13.
7
Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen.瓦尔堡、我与己糖激酶2：对癌症最常见表型之一“瓦尔堡效应”（即在有氧情况下糖酵解增强）背后关键分子事件的多项发现。
J Bioenerg Biomembr. 2007 Jun;39(3):211-22. doi: 10.1007/s10863-007-9094-x.
8
Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma.己糖激酶II抑制剂对肝癌的促凋亡抗肿瘤疗效
Mol Cancer Ther. 2007 Sep;6(9):2554-62. doi: 10.1158/1535-7163.MCT-07-0115.
9
[Expression of hexokinase-II gene in human colon cancer cells and the therapeutic significance of inhibition thereof].[己糖激酶-II基因在人结肠癌细胞中的表达及其抑制的治疗意义]
Zhonghua Yi Xue Za Zhi. 2007 Apr 17;87(15):1058-62.
10
Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells.2-脱氧-D-葡萄糖与2-氟脱氧-D-葡萄糖在缺氧和常氧肿瘤细胞中的差异毒性机制
Antioxid Redox Signal. 2007 Sep;9(9):1383-90. doi: 10.1089/ars.2007.1714.
Zotero 插件