Fuggle Susan V, Martin Susan
Transplantation. 2008 Aug 15;86(3):384-90. doi: 10.1097/TP.0b013e31817c90f5.
In recent years there have been major advances in the technology for the detection and definition of human leukocyte antigen antibodies. In this overview we describe the evolution in laboratory technology, the techniques currently available and consider their application in antibody specificity definition and in understanding a patient's sensitization profile. We discuss the importance of antibody specificity definition in facilitating efficient national organ allocation and informing clinical discussion regarding the appropriate pathway for sensitized patients awaiting renal transplantation.
近年来，人类白细胞抗原抗体的检测和鉴定技术取得了重大进展。在本综述中，我们描述了实验室技术的发展、当前可用的技术，并探讨了它们在抗体特异性鉴定以及了解患者致敏情况方面的应用。我们讨论了抗体特异性鉴定在促进国家器官有效分配以及为等待肾移植的致敏患者的适当治疗途径提供临床讨论依据方面的重要性。
