Hecht Jonathan L, Dolinski Brian M, Gardner Humphrey A, Violette Shelia M, Weinreb Paul H
Biogen Idec, Cambridge, MA, USA.
Appl Immunohistochem Mol Morphol. 2008 Dec;16(6):543-7. doi: 10.1097/PAI.0b013e31816bc5ee.
The alpha(v)beta(6) integrin (alphavbeta6) has been shown to be up-regulated in adenocarcinoma of the breast, colon, stomach, and ovary, generally reflecting a more aggressive phenotype. Expression in endometrial cancer has not been reported. We analyzed alphavbeta6 expression in the tissue from primary endometrial carcinomas (endometrioid type) using a mouse monoclonal antibody against human alphavbeta6, and correlated the findings with grade, stage, and nodal involvement. Normal cycling endometrium was studied for comparison. alphavbeta6 was only weakly expressed in normal epithelium and infrequently expressed in precancers, but up-regulated in the majority of endometrial carcinomas, especially with high grade. Nodal metastases strongly expressed alphavbeta6, even when the primary tumor showed only focal expression. No correlation was found between expression and depth of invasion or the presence of metastases. Overexpression of alphavbeta6 in endometrial carcinoma is common. Expression is high in metastatic lesions. The level of expression of the primary tumor was not indicative of the presence of nodal metastasis; however, the number of cases with nodal metastases was limited.
α(v)β(6)整合素（αvβ6）已被证明在乳腺癌、结肠癌、胃癌和卵巢癌中上调，通常反映出更具侵袭性的表型。子宫内膜癌中的表达尚未见报道。我们使用抗人αvβ6的小鼠单克隆抗体分析了原发性子宫内膜癌（子宫内膜样型）组织中的αvβ6表达，并将结果与分级、分期和淋巴结受累情况相关联。为作比较，对正常周期性子宫内膜进行了研究。αvβ6在正常上皮中仅弱表达，在癌前病变中很少表达，但在大多数子宫内膜癌中上调，尤其是高级别癌。即使原发性肿瘤仅表现为局灶性表达，淋巴结转移灶也强烈表达αvβ6。未发现表达与浸润深度或转移的存在之间存在相关性。αvβ6在子宫内膜癌中过表达很常见。转移灶中表达较高。原发性肿瘤的表达水平不能指示淋巴结转移的存在；然而，有淋巴结转移的病例数量有限。
