Bakri Sophie J, Ekdawi Noha S
Department of Ophthalmology, Vitreoretinal Diseases and Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
Retina. 2008 Jul-Aug;28(7):996-1001. doi: 10.1097/IAE.0b013e31816c6868.
To present the finding of tiny silicone oil droplets in 15 eyes of 15 patients after intravitreal injections of an anti-vascular endothelial growth factor agent or triamcinolone acetonide and to discuss the likely source of silicone oil.
In an observational case series, charts of patients who had undergone intravitreal injections by one surgeon were reviewed retrospectively. The finding of intravitreal silicone oil droplets was noted. The following information was also documented: number and type of injections before the appearance of silicone oil droplets, symptoms and evidence of ocular inflammation, visual acuity before and after silicone oil droplets, length of follow-up, and visual acuity at the last examination.
Fifteen eyes of 15 patients were found to have silicone oil droplets documented after a various number of injections (range, 1-16). Patients were asymptomatic, and there were no adverse side effects associated with the presence of silicone oil droplets at examination.
Silicone oil droplets may occur in the vitreous cavity after intravitreal drug injections. There were no adverse effects found associated with silicone oil in the vitreous after injections of anti-vascular endothelial growth factor agents or triamcinolone acetonide. The likely source of silicone oil is the needles and syringes used for the injections.
报告15例患者在玻璃体内注射抗血管内皮生长因子药物或曲安奈德后，15只眼中发现微小硅油滴的情况，并讨论硅油的可能来源。
在一个观察性病例系列中，对由一名外科医生进行玻璃体内注射的患者病历进行回顾性研究。记录玻璃体内硅油滴的发现情况。还记录了以下信息：出现硅油滴之前的注射次数和类型、眼部炎症的症状和证据、出现硅油滴前后的视力、随访时间以及最后一次检查时的视力。
15例患者的15只眼中在不同次数的注射后（范围为1 - 16次）发现有硅油滴记录。患者无症状，检查时硅油滴的存在未伴有不良副作用。
玻璃体内注射药物后，玻璃体腔中可能出现硅油滴。在注射抗血管内皮生长因子药物或曲安奈德后，未发现玻璃体中的硅油有不良影响。硅油的可能来源是用于注射的针头和注射器。
