Krieger J N, Coombs R W, Collier A C, Koehler J K, Ross S O, Chaloupka K, Murphy V L, Corey L
Department of Urology, University of Washington School of Medicine, Seattle 98195.
J Infect Dis. 1991 Sep;164(3):464-9. doi: 10.1093/infdis/164.3.464.
The effect of human immunodeficiency virus type 1 (HIV) infection on semen parameters that assess fertility was investigated in 50 semen specimens from 21 asymptomatic or minimally symptomatic HIV-seropositive men and 3 specimens from 3 men with AIDS. HIV was isolated from 15 (30%) of 50 specimens from asymptomatic or minimally symptomatic persons and from 1 of 3 specimens from patients with AIDS. The men with AIDS all had pyosemia and grossly abnormal sperm. In contrast, semen specimens from other seropositive men did not differ significantly from semen specimens from healthy seronegative semen donors. No abnormality in sperm count, morphology, numbers or types of leukocytes in semen, or other seminal parameters was associated with HIV shedding in semen. Zidovudine therapy did not affect sperm morphology or seminal characteristics. Thus, although patients with AIDS had abnormal semen, the laboratory parameters that assess fertility were not affected by shedding of HIV in semen or concomitant therapy with zidovudine.
研究了1型人类免疫缺陷病毒（HIV）感染对评估生育能力的精液参数的影响，共检测了21名无症状或症状轻微的HIV血清阳性男性的50份精液标本，以及3名艾滋病男性的3份精液标本。在50份来自无症状或症状轻微者的标本中有15份（30%）分离出HIV，在3份来自艾滋病患者的标本中有1份分离出HIV。艾滋病患者均有脓血症且精子严重异常。相比之下，其他血清阳性男性的精液标本与健康血清阴性精液供者的精液标本无显著差异。精液中的精子计数、形态、白细胞数量或类型以及其他精液参数的异常均与精液中HIV排出无关。齐多夫定治疗不影响精子形态或精液特征。因此，尽管艾滋病患者精液异常，但评估生育能力的实验室参数不受精液中HIV排出或齐多夫定联合治疗的影响。
