Berry J J, Baker J A, Pieper K S, Hanson M W, Hoffman J M, Coleman R E
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.
J Nucl Med. 1991 Aug;32(8):1518-25.
Cardiac PET imaging using 13N-ammonia and 18FDG was performed on 17 normal volunteers in the glucose-loaded and fasted states. PET images (glucose-loaded and fasted) were subjected to qualitative visual analysis using the descriptors: image quality, FDG blood-pool activity, ammonia lung field activity, and clinical interpretability. Glucose-loaded studies had better image quality, diminished FDG blood-pool activity, and were more often clinically interpretable compared to fasted studies. Dietary state did not affect 13N-ammonia study parameters. Using a semi-quantitative region of interest method, 18FDG myocardial activity was homogeneous and significantly affected by dietary state (2.48 +/- 1.0 fold increase in myocardial-to-blood pool ratio in glucose-loaded versus fasted states). Serum glucose, insulin, and free-fatty acid concentrations responded physiologically to glucose loading and fasting but showed no correlation with myocardial 18FDG uptake. PET imaging using 13N-ammonia and 18FDG appears optimal in the glucose-loaded state.
对17名正常志愿者在葡萄糖负荷状态和禁食状态下进行了使用¹³N-氨和¹⁸F-FDG的心脏PET成像。PET图像（葡萄糖负荷状态和禁食状态）采用以下描述词进行定性视觉分析：图像质量、FDG血池活性、氨肺野活性和临床可解释性。与禁食状态的研究相比，葡萄糖负荷状态的研究图像质量更好，FDG血池活性降低，且在临床上更常具有可解释性。饮食状态不影响¹³N-氨的研究参数。采用半定量感兴趣区方法，¹⁸F-FDG心肌活性均匀，且受饮食状态显著影响（葡萄糖负荷状态与禁食状态相比，心肌与血池比值增加2.48±1.0倍）。血清葡萄糖、胰岛素和游离脂肪酸浓度对葡萄糖负荷和禁食有生理反应，但与心肌¹⁸F-FDG摄取无相关性。使用¹³N-氨和¹⁸F-FDG的PET成像在葡萄糖负荷状态下似乎最为理想。
