Al-barwani Sulayma A, Bayoumi Riad A, Jaju Deepali, Al-Yahyaee Saeed A S, Al-Hadabi Saleh, Lopez-Alvarenga Juan C, Comuzzie Anthony G, Hassan Mohammed O
College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Metab Syndr Relat Disord. 2008 Sep;6(3):197-202. doi: 10.1089/met.2008.0009.
The aim of this study was to investigate causes of the prevalence of the metabolic syndrome in multiparous Omani Arab women using the International Diabetes Federation definition (IDF).
Of 392 married women (mean age 40 years), 354 (90%) were multiparous with an average parity of 8. They were divided into four parity groups: Para 0, Para 1-3, Para 4-6, and Para >6. Body mass index (BMI), waist circumference, fasting, and 2-hour glucose and insulin, plasma lipids, serum leptin, and homeostasis model assessment for insulin resistance (HOMA-IR) and blood pressure (BP) were measured.
In the whole cohort, the IDF definition identified 28% women with the metabolic syndrome, whereas it identified 48% in Para >6. In comparison, the National Cholesterol Education Program (NCEP) definition identified 21% and 39%, respectively (kappa = 0.642). Waist circumference was positively associated with the number of live births (beta = 0.78, p = 0.0001). Compared to other individual IDF criteria, only age-adjusted large waist circumference carried the highest risk for having the metabolic syndrome in all groups (odds ratio [OR], 2.3, 95% confidence interval [CI], 1.0-5.4, 3.2, CI, 1.3-8 and 4.8, CI, 2.1-11.2).
The high prevalence of the metabolic syndrome in multiparous Omani Arab women appeared to be influenced by the parity-related large waist circumference. The high dependency of the IDF criteria on waist circumference for the definition of the metabolic syndrome in this population has led to the misclassification of such women.
本研究旨在采用国际糖尿病联盟（IDF）的定义，调查阿曼阿拉伯经产妇代谢综合征患病率的原因。
在392名已婚女性（平均年龄40岁）中，354名（90%）为经产妇，平均产次为8次。她们被分为四个产次组：未生育组、1 - 3次生育组、4 - 6次生育组和大于6次生育组。测量了体重指数（BMI）、腰围、空腹及餐后2小时血糖和胰岛素、血脂、血清瘦素、胰岛素抵抗稳态模型评估（HOMA - IR）和血压（BP）。
在整个队列中，IDF定义识别出28%的女性患有代谢综合征，而在大于6次生育组中这一比例为48%。相比之下，美国国家胆固醇教育计划（NCEP）的定义分别识别出21%和39%（kappa = 0.642）。腰围与活产次数呈正相关（β = 0.78，p = 0.0001）。与其他个体IDF标准相比，在所有组中，仅年龄调整后的大腰围患代谢综合征的风险最高（优势比[OR]，2.3，95%置信区间[CI]，1.0 - 5.4；3.2，CI，1.3 - 8；4.8，CI，2.1 - 11.2）。
阿曼阿拉伯经产妇代谢综合征的高患病率似乎受到与产次相关的大腰围的影响。在该人群中，IDF标准对腰围在代谢综合征定义上的高度依赖性导致了此类女性的误诊。
