Daemen B J, Elsinga P H, Mooibroek J, Paans A M, Wieringa A R, Konings A W, Vaalburg W
Department of Nuclear Medicine, University Hospital, Groningen, The Netherlands.
J Nucl Med. 1991 Aug;32(8):1587-92.
Hyperthermia-induced metabolic changes in tumor tissue have been monitored by PET. Uptake of L-[1-11C]tyrosine in rhabdomyosarcoma tissue of Wag/Rij rats was dose-dependently reduced after local hyperthermia treatment at 42, 45, or 47 degrees C. Tumor blood flow, as measured by PET with 13NH3, appeared to be unchanged. The L-[1-11C]tyrosine uptake data were compared to uptake data of L-[1-14C]tyrosine and with data on the incorporation of L-[1-14C]tyrosine into tumor proteins. After intravenous injection, the 14C data were obtained from dissected tumor tissue. Heat-induced inhibition of the incorporation of L-[1-14C]tyrosine into tumor proteins tallied with the L-[1-11C]tyrosine uptake data. Heat-induced inhibition of amino acid uptake in the tumor correlated well with regression of tumor growth. It is concluded that PET using L-[1-11C]tyrosine is eligible for monitoring the effect of hyperthermia on tumor growth.
正电子发射断层扫描（PET）已用于监测热疗引起的肿瘤组织代谢变化。在42、45或47摄氏度进行局部热疗后，Wag/Rij大鼠横纹肌肉瘤组织中L-[1-11C]酪氨酸的摄取呈剂量依赖性降低。通过用13NH3进行PET测量的肿瘤血流似乎未发生变化。将L-[1-11C]酪氨酸摄取数据与L-[1-14C]酪氨酸摄取数据以及L-[1-14C]酪氨酸掺入肿瘤蛋白的数据进行了比较。静脉注射后，从解剖的肿瘤组织中获得14C数据。热诱导的L-[1-14C]酪氨酸掺入肿瘤蛋白的抑制与L-[1-11C]酪氨酸摄取数据相符。热诱导的肿瘤中氨基酸摄取的抑制与肿瘤生长的消退密切相关。得出的结论是，使用L-[1-11C]酪氨酸的PET有资格监测热疗对肿瘤生长的影响。
