胸腺瘤切除术后副肿瘤性天疱疮消退
Paraneoplastic pemphigus regression after thymoma resection.
作者信息
Barbetakis Nikolaos, Samanidis Georgios, Paliouras Dimitrios, Boukovinas Ioannis, Asteriou Christos, Stergiou Eleni, Laschos Kostas, Tsilikas Christodoulos
机构信息
Thoracic Surgery Department, Theagenio Cancer Hospital, Thessaloniki, Greece.
出版信息
World J Surg Oncol. 2008 Aug 12;6:83. doi: 10.1186/1477-7819-6-83.
BACKGROUND
Among human neoplasms thymomas are associated with highest frequency with paraneoplastic autoimmune diseases.
CASE PRESENTATION
A case of a 42-year-old woman with paraneoplastic pemphigus as the first manifestation of thymoma is reported. Transsternal complete thymoma resection achieved pemphigus regression. The clinical correlations between pemphigus and thymoma are presented.
CONCLUSION
Our case report provides further evidence for the important role of autoantibodies in the pathogenesis of paraneoplastic skin diseases in thymoma patients. It also documents the improvement of the associated pemphigus after radical treatment of the thymoma.
背景
在人类肿瘤中，胸腺瘤与副肿瘤性自身免疫性疾病的关联最为频繁。
病例报告
报告一例42岁女性，以副肿瘤性天疱疮为胸腺瘤的首发表现。经胸骨全胸腺切除术使天疱疮病情缓解。阐述了天疱疮与胸腺瘤之间的临床相关性。
结论
我们的病例报告为自身抗体在胸腺瘤患者副肿瘤性皮肤病发病机制中的重要作用提供了进一步证据。它还记录了胸腺瘤根治性治疗后相关天疱疮病情的改善情况。
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