Brain dopamine response in human opioid addiction.
作者信息
Daglish Mark R C, Williams Tim M, Wilson Sue J, Taylor Lindsay G, Eap Chin B, Augsburger Marc, Giroud Christian, Brooks David J, Myles Judy S, Grasby Paul, Lingford-Hughes Anne R, Nutt David J
机构信息
Psychopharmacology Unit, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, UK.
出版信息
Br J Psychiatry. 2008 Jul;193(1):65-72. doi: 10.1192/bjp.bp.107.041228.
BACKGROUND
Drugs of dependence cause dopamine release in the rat striatum. Human neuroimaging studies have shown an increase in dopamine in the equivalent region in response to stimulants and other drugs.
AIMS
We tested whether opioids provoke dopamine release and its relationship to the subjective experience.
METHOD
In two combined studies 14 heroin addicts on methadone maintenance treatment underwent two positron emission tomography brain scans of the dopamine system using [(11)C]-raclopride following an injection of placebo and either 50 mg intravenous diamorphine or 10 mg subcutaneous hydromorphone in a double-blind, random order design.
RESULTS
Both opioids produced marked subjective and physiological effects, but no measurable change in [(11)C]-raclopride binding.
CONCLUSIONS
The absence of a dopamine response to opioid agonists contrasts with that found with stimulant drugs and suggests dopamine may not play the same role in addiction to opioids. This questions the role of dopamine in the subjective experience of heroin in opioid addicts.
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