对N-甲基-D-天冬氨酸（NMDA）和成瘾感到困惑？靶向基因敲除给出了答案，也带来了新问题。
Confused about NMDA and addiction? Targeted knockouts provide answers and new questions.
作者信息
Carr David B, Kalivas Peter W
机构信息
Department of Neurosciences, Medical University of South Carolina, Charleston, Charleston, SC 29425, USA.
出版信息
Neuron. 2008 Aug 14;59(3):353-5. doi: 10.1016/j.neuron.2008.07.025.
NMDA-dependent plasticity in VTA dopamine neurons has been hypothesized to be an important first step in the development of long-term changes in the brain reward circuitry that underlie addiction. Two papers from Zweifel et al. and Engblom et al. in this issue of Neuron raise new questions concerning the role of NMDA receptors within VTA dopamine neurons in mediating the behavioral effects of drugs of abuse.
伏隔核多巴胺能神经元中依赖N-甲基-D-天冬氨酸（NMDA）的可塑性被认为是大脑奖赏回路长期变化发展过程中的重要第一步，而这种长期变化是成瘾的基础。在本期《神经元》杂志上，兹韦费尔等人和恩布洛姆等人发表的两篇论文对NMDA受体在伏隔核多巴胺能神经元中介导滥用药物行为效应的作用提出了新问题。
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