钙蛋白酶-10的111/121双倍型与韩国女性患多囊卵巢综合征的风险相关。
111/121 diplotype of Calpain-10 is associated with the risk of polycystic ovary syndrome in Korean women.
作者信息
Lee Ji Young, Lee Woon Jeong, Hur Sung Eun, Lee Chul Min, Sung Yeon-Ah, Chung Hye Won
机构信息
Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Korea.
出版信息
Fertil Steril. 2009 Aug;92(2):830-3. doi: 10.1016/j.fertnstert.2008.06.023. Epub 2008 Aug 13.
We investigated whether the CAPN-10 polymorphism UCSNP-43, -19, and -63 contribute, either individually or as haplotype/diplotype, to the susceptibility of polycystic ovary syndrome (PCOS) or related quantitative traits in Korean women. Our data showed that 111 haplotype and 111/121 and 111/111 diplotypes in the CAPN-10 gene were associated with a significantly increased risk of PCOS, and 112 haplotype and 121/121 and 112/122 diplotypes were associated with decreased risk of PCOS in the Korean population.
我们研究了钙蛋白酶-10基因多态性UCSNP-43、-19和-63是单独作用，还是作为单倍型/双倍型，对韩国女性多囊卵巢综合征（PCOS）的易感性或相关数量性状产生影响。我们的数据显示，钙蛋白酶-10基因中的111单倍型以及111/121和111/111双倍型与PCOS风险显著增加相关，而112单倍型以及121/121和112/122双倍型与韩国人群中PCOS风险降低相关。
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