中国多囊卵巢综合征女性中CYP11a基因启动子的微卫星多态性（tttta）n
A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome.
作者信息
Wang Yong, Wu XiaoKe, Cao Yunxia, Yi Long, Chen Jianxiu
机构信息
Human Genetic Identification Laboratory, Medical School of Nanjing University, Nanjing, China.
出版信息
Fertil Steril. 2006 Jul;86(1):223-6. doi: 10.1016/j.fertnstert.2005.12.037. Epub 2006 Jun 9.
A (tttta)n microsatellite polymorphism in the promoter of CYP11a gene was investigated in 201 Chinese Han women with polycystic ovary syndrome (PCOS) and 147 control women. The 6/6 genotype was defined with significant difference of CYP11a polymorphism between women with PCOS and control women, and associated with greater BMI in PCOS patients, suggesting a certain role of the six-repeat allele variant in the pathogenesis of Chinese women with PCOS.
在201名患有多囊卵巢综合征（PCOS）的中国汉族女性和147名对照女性中，研究了CYP11a基因启动子中的A（tttta）n微卫星多态性。定义了6/6基因型，PCOS女性和对照女性之间CYP11a多态性存在显著差异，并且与PCOS患者更高的体重指数相关，这表明六重复等位基因变体在中国PCOS女性发病机制中起一定作用。
Zotero 插件