Seyhan Ekrem Cengiz, Cetinkaya Erdoğan, Altin Sedat, Gençoğlu Atayla, Simşek Nurdan
Yedikule Chest Diseases and Chest Surgery Education and Research Hospital, Istanbul, Turkey.
Tuberk Toraks. 2008;56(2):163-70.
Our study aimed to determine the frequency of sick euthyroid syndrome (SES) among patients diagnosed as non-small cell lung cancer (NSCLC) and its association with the stage of the disease, Karnofsky index (KI), and nutritional parameters. We enrolled 80 consecutive patients with newly diagnosed NSCLC. Cases with NSCLC were staged by using TNM system. The cases were examined for thyroid function tests, KI and nutritional evaluation before treatment. Moreover, cases were investigated for their overall survival ratio at sixth, twelfth, and eighteenth months. Out of 80 patients, sick euthyroid syndrome (SES) were identified in 28 (35%). SES was more frequent among stage III (26%) and stage IV (62%) cases. The body mass index (BMI), KI and serum albumin level were detected to be significantly low in cases with SES when compared to cases without SES. SES was found to be negatively correlated with BMI, KI and serum albumin level, and it was positively correlated with disease stage. SES was frequently seen in cases with NSCLC. SES can be used as a predictor of poor prognosis.
我们的研究旨在确定被诊断为非小细胞肺癌（NSCLC）的患者中病态甲状腺综合征（SES）的发生率及其与疾病分期、卡诺夫斯基指数（KI）和营养参数的关联。我们连续纳入了80例新诊断的NSCLC患者。NSCLC病例采用TNM系统进行分期。在治疗前对病例进行甲状腺功能测试、KI和营养评估。此外，还调查了病例在第六、十二和十八个月时的总生存率。在80例患者中，28例（35%）被诊断为病态甲状腺综合征（SES）。SES在III期（26%）和IV期（62%）病例中更为常见。与无SES的病例相比，SES病例的体重指数（BMI）、KI和血清白蛋白水平显著降低。发现SES与BMI、KI和血清白蛋白水平呈负相关，与疾病分期呈正相关。SES在NSCLC病例中很常见。SES可作为预后不良的预测指标。
