Choy Young Bin, Cheng Felice, Choi Hyungsoo, Kim Kyekyoon Kevin
Department of Electrical and Computer Engineering, Thin Film and Charged Particle Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Macromol Biosci. 2008 Dec 8;8(12):1173-81. doi: 10.1002/mabi.200800079.
Uniform chitosan microspheres have been fabricated and weakly crosslinked for potential applications in colon-specific drug delivery. The effects of microsphere size, crosslinking density and electrostatic interactions between the drug and chitosan on drug release were studied, employing model drugs of different acidities. When the drug was basic, all chitosan spheres exhibited 100% release within 30 min. As the acidity of the drug increased, the release slowed down and depended on the crosslinking density and microsphere size. The release of weakly acidic drug was most suppressed for large spheres (35-38 microm), while the small spheres (23-25 microm) with higher crosslinking exhibited the most retention of highly acidic drug, indicating that they are a promising candidate for colon-specific delivery.
已制备出均匀的壳聚糖微球并进行了弱交联，以用于结肠特异性药物递送的潜在应用。使用不同酸度的模型药物，研究了微球尺寸、交联密度以及药物与壳聚糖之间的静电相互作用对药物释放的影响。当药物呈碱性时，所有壳聚糖微球在30分钟内均表现出100%的释放率。随着药物酸度的增加，释放速度减慢，且取决于交联密度和微球尺寸。对于大尺寸微球（35 - 38微米），弱酸性药物的释放受到最大抑制，而具有较高交联度的小尺寸微球（23 - 25微米）对高酸性药物的保留率最高，这表明它们是结肠特异性递送的有前景的候选材料。
