Angelopoulos Theodore J, Miles Mary P, Lowndes Joshua, Sivo Stephen A, Seip Richard L, Pescatello Linda S, Zoeller Robert F, Visich Paul S, Gordon Paul M, Moyna Niall M, Thompson Paul D
Center for Lifestyle Medicine and Department of Health Professions, University of Central Florida, Orlando, FL 32826, USA.
Metabolism. 2008 Sep;57(9):1204-10. doi: 10.1016/j.metabol.2008.04.013.
C-reactive protein (CRP) is a marker for systemic inflammation and increased cardiovascular disease risk. Regular exercise may decrease CRP. Apolipoprotein E (apo E) has 3 common genotype variants--E2/3, 3/3, and 3/4--that modulate lipid metabolism and may have other metabolic physiologic roles, including some evidence that the genotype affects CRP levels. We assessed fasting serum CRP in 117 (male = 51, female = 66) healthy adults who volunteered for a 6-month aerobic exercise program. Both pre- and posttraining measurements were available in 71 (male = 31, female = 40) subjects. At baseline and follow-up, the numbers of subjects in the 3 groups were approximately equal: 2/3, n = 33 and 20; 3/3, n = 41 and 26; and 3/4, n = 43 and 25. At baseline, CRP levels differed by apo E genotype: means +/- SD were 2.84 +/- 2.18, 2.59 +/- 2.34, and 1.90 +/- 2.13 mg/L for E2/3, 3/3, and 3/4 subjects, respectively (3/4 vs 2/3, P < .05). In women, CRP was higher than that in men (3.14 +/- 2.49 vs 2.12 +/- 2.13 mg/L, P < .006). Exercise failed to affect CRP in the entire cohort (2.68 +/- 2.38 vs 2.52 +/- 2.48 mg/L) or in any apo E genotype group, and the apo E genotype effect observed at baseline persisted after training. In a largely white study cohort, CRP is higher in apo E3/3 than in 3/4 subjects and in women compared with men, but remains unchanged by 6 months of standard aerobic exercise training of the volume and higher intensity promoted by national organizations to reduce cardiovascular disease risk. How apo E genotype affects CRP is not known.
C反应蛋白（CRP）是全身炎症和心血管疾病风险增加的一个标志物。规律运动可能会降低CRP水平。载脂蛋白E（apo E）有3种常见的基因型变体——E2/3、3/3和3/4——它们可调节脂质代谢，可能还具有其他代谢生理作用，包括有证据表明该基因型会影响CRP水平。我们评估了117名（男性51名，女性66名）自愿参加为期6个月有氧运动计划的健康成年人的空腹血清CRP水平。71名（男性31名，女性40名）受试者提供了训练前和训练后的测量数据。在基线和随访时，3组中的受试者数量大致相等：E2/3组，n = 33和20；3/3组，n = 41和26；3/4组，n = 43和25。在基线时，CRP水平因apo E基因型而异：E2/3、3/3和3/4受试者的均值±标准差分别为2.84±2.18、2.59±2.34和1.90±2.13mg/L（3/4组与2/3组相比，P < 0.05）。在女性中，CRP高于男性（3.14±2.49 vs 2.12±2.13mg/L，P < 0.006）。运动未能影响整个队列的CRP水平（2.68±2.38 vs 2.52±2.48mg/L），也未影响任何apo E基因型组，且训练后基线时观察到的apo E基因型效应依然存在。在一个主要为白人的研究队列中，apo E3/3受试者的CRP高于3/4受试者，女性高于男性，但通过国家组织推广的旨在降低心血管疾病风险的标准有氧运动训练（该训练的量和强度更高），6个月后CRP水平仍未改变。apo E基因型如何影响CRP尚不清楚。
