Yamamoto Chika, Urano Akiko, Fujiwara Yasuyuki, Kaji Toshiyuki
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan.
Life Sci. 2008 Sep 12;83(11-12):447-52. doi: 10.1016/j.lfs.2008.07.008. Epub 2008 Jul 29.
Adiponectin, which is an adipose-specific plasma protein, exhibits antiatherogenic activities. The purpose of the present study is to demonstrate that adiponectin regulates the synthesis of proteoglycans-macromolecules comprising a core protein and glycosaminoglycan side chains involved in atherosclerosis progression-in vascular smooth muscle cells.
In the present study, proteoglycans obtained from cultured, adiponectin-treated human coronary artery smooth muscle cells were characterized using biochemical techniques.
The results indicated that adiponectin induces the synthesis of decorin-a small dermatan sulfate proteoglycan-in vascular smooth muscle cells. Furthermore, the length of dermatan sulfate chains of the decorin molecule appeared to remain unchanged, but the epimerization of glucuronic acid in the chains decreased.
Although the significance of the regulation of decorin synthesis in atherosclerosis progression by adiponectin remains to be determined, the present study demonstrates for the first time that adiponectin regulates proteoglycan synthesis in vascular smooth muscle cells.
脂联素是一种脂肪特异性血浆蛋白，具有抗动脉粥样硬化活性。本研究的目的是证明脂联素可调节血管平滑肌细胞中蛋白聚糖的合成，蛋白聚糖是一种由核心蛋白和参与动脉粥样硬化进展的糖胺聚糖侧链组成的大分子。
在本研究中，使用生化技术对从培养的、经脂联素处理的人冠状动脉平滑肌细胞中获得的蛋白聚糖进行了表征。
结果表明，脂联素可诱导血管平滑肌细胞中核心蛋白聚糖（一种小的硫酸皮肤素蛋白聚糖）的合成。此外，核心蛋白聚糖分子的硫酸皮肤素链长度似乎保持不变，但链中葡萄糖醛酸的差向异构化减少。
尽管脂联素对核心蛋白聚糖合成的调节在动脉粥样硬化进展中的意义尚待确定，但本研究首次证明脂联素可调节血管平滑肌细胞中蛋白聚糖的合成。
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