Notash Ali Yaghoobi, Notash Aidin Yaghoobi, Amoli Hadi Ahmadi, Konari Adel Yazdankhah, Daemi Mahrokh, Alizadeh Kamyab, Habibi Gholamreza
Department of Surgery, Tehran University of Medical Sciences, Sina Trauma and Surgery Research Center, Tehran, Iran.
Hepatogastroenterology. 2008 May-Jun;55(84):883-6.
BACKGROUND/AIMS: The aim of this study was to identify factors most relevant to postoperative nausea and vomiting (PONV) and determine the association of Helicobacter pylori with PONV.
A cross-sectional analytic survey was conducted on 127 elective patients who underwent general and urological surgery at Sina Hospital in Tehran between March 2005 and March 2006. Related factors considered to have a possible effect on the prevalence of PONV events were evaluated by using a special questionnaire and serological laboratory test of H. pylori. Data was analyzed using t test and chi2 test and logistic regression analysis for comparing the variables.
Prevalence of PONV was 54.7% in patients having H. pylori infection. There was no relationship between H. pylori infection and PONV (p>0.05). Prior history of PONV was a significant risk factor for increasing the prevalence of PONV (p<0.05). Also, history of PONV beside female gender, overweighting/obesity and operation type (urologic surgery) could increase the severity of PONV (p<0.05). But, administration of opioids could decrease the severity of PONV (p<0.05).
It was found that PONV had a high prevalence among patients undergoing urologic and general surgery. H. pylori infection cannot affect the prevalence of PONV. More surveys are needed to develop effective protocols for preventing this common and unpleasant problem.
背景/目的：本研究旨在确定与术后恶心呕吐（PONV）最相关的因素，并确定幽门螺杆菌与PONV之间的关联。
对2005年3月至2006年3月期间在德黑兰新浪医院接受普通外科和泌尿外科手术的127例择期手术患者进行了横断面分析调查。通过使用特殊问卷和幽门螺杆菌血清学实验室检测，评估了被认为可能对PONV事件发生率有影响的相关因素。使用t检验、卡方检验和逻辑回归分析对数据进行分析，以比较各变量。
幽门螺杆菌感染患者的PONV发生率为54.7%。幽门螺杆菌感染与PONV之间无关联（p>0.05）。PONV既往史是增加PONV发生率的一个重要危险因素（p<0.05）。此外，除了女性性别、超重/肥胖和手术类型（泌尿外科手术）外，PONV既往史还会增加PONV的严重程度（p<0.05）。但是，使用阿片类药物可降低PONV的严重程度（p<0.05）。
研究发现，PONV在接受泌尿外科和普通外科手术的患者中发生率较高。幽门螺杆菌感染不会影响PONV的发生率。需要进行更多调查，以制定有效的方案来预防这一常见且令人不适的问题。
