Luef G, Krämer G, Stefan H
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Acta Neurol Scand. 2009 Feb;119(2):94-9. doi: 10.1111/j.1600-0404.2008.01085.x. Epub 2008 Aug 14.
To collect data on sexual dysfunction in a larger population of male patients with epilepsy treated with oxcarbazepine in a naturalistic setting.
Six hundred seventy-three adult male patients with partial epilepsy in whom monotherapy with oxcarbazepine was indicated were evaluated at baseline and after approximately 12 weeks of treatment with regard to the number of seizures and occurrence of any adverse drug reactions. All patients were questioned regarding their sexual function.
Out of 228 patients with pre-existing sexual function impairment at baseline, an improvement was observed in 181 (79.4%) patients, 23 (10.1%) patients experienced no impairment at the final visit. The improvements were more marked in those patients, who were pretreated with enzyme-inducing antiepileptic drugs. No worsening of the sexual dysfunction was observed.
Oxcarbazepine was found to have beneficial effects on sexual dysfunction and to be effective and well tolerated in male patients with partial epilepsy.
在自然环境下，收集更多接受奥卡西平治疗的男性癫痫患者性功能障碍的数据。
对673例成年男性部分性癫痫患者进行评估，这些患者被指示使用奥卡西平进行单药治疗，在基线时以及治疗约12周后评估癫痫发作次数和任何药物不良反应的发生情况。所有患者均被询问其性功能。
在基线时已有性功能障碍的228例患者中，181例（79.4%）患者有改善，23例（10.1%）患者在最后一次访视时无功能障碍。在那些预先使用酶诱导抗癫痫药物治疗的患者中，改善更为明显。未观察到性功能障碍恶化。
发现奥卡西平对性功能障碍有有益作用，对男性部分性癫痫患者有效且耐受性良好。
