Szabo Kristina, Kern Rolf, Hennerici Michael G
Department of Neurology, Universitätsklinikum Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Int J Stroke. 2007 May;2(2):97-103. doi: 10.1111/j.1747-4949.2007.00103.x.
The management of patients with internal carotid artery stenosis needs to focus on the occurrence and identification of neurological symptoms, the degree and morphology of the stenosis and the determination of the mechanism of cerebral ischemia. Thus neuroimaging studies are an integral part of the neurologist's assessment of these patient and individual therapeutic decisions. Since a differentiated approach is not always taken and patients by far too often undergo surgical or interventional treatment without a proper neurological evaluation, the material presented in this review demonstrates the possibilities of such a critical assessment concerning brain and vascular imaging findings and new techniques as well as modern concepts of plaque vulnerability improving the understanding of the pathophysiology and mechanisms of ischemic symptoms in internal carotid artery disease. Furthermore, the results of recent clinical trails that need to be integrated in the optimal treatment plan of these patients are discussed.
颈内动脉狭窄患者的管理需要关注神经症状的发生与识别、狭窄的程度和形态以及脑缺血机制的判定。因此,神经影像学检查是神经科医生对这些患者进行评估及做出个体化治疗决策不可或缺的一部分。由于并非总是采取差异化的方法,而且患者常常在没有进行适当神经评估的情况下就接受手术或介入治疗,本综述所呈现的资料展示了对脑和血管影像学检查结果及新技术进行这种关键评估的可能性,以及斑块易损性的现代概念,有助于加深对颈内动脉疾病缺血症状的病理生理学和机制的理解。此外,还讨论了近期临床试验的结果,这些结果需要纳入这些患者的最佳治疗方案中。