Maezawa Hitoshi, Yoshida Kazuya, Nagamine Takashi, Matsubayashi Jun, Enatsu Rei, Bessho Kazuhisa, Fukuyama Hidenao
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.
Neurosci Res. 2008 Oct;62(2):131-9. doi: 10.1016/j.neures.2008.07.004. Epub 2008 Jul 29.
Quantitative evaluation of the sensory disturbance of the tongue is important clinically. However, because the conventional electrophysiological approach to the peripheral nerve cannot be used in the mandible owing to the deep route of the lingual nerve, we applied evoked potentials in the central nervous system. Somatosensory evoked magnetic fields (SEFs) following electric stimulation were recorded in 10 healthy subjects by means of pin electrodes placed on the tongue mucosa. Three or four components (P25m, P40m, P60m, and P80m) were identified over the contralateral hemisphere with unilateral stimulation. Because none of the components were consistently detected in all subjects, we evaluated the root mean square (RMS) of 18 channels over the contralateral hemisphere. To estimate the activated cortical response, we calculated the difference in mean RMS amplitude between 10 and 150 ms and that of the baseline period (aRMS=RMS[10, 150]-RMS[-50, -5]). The aRMS values for right-sided and left-sided stimulation were 10.18+/-7.92 and 10.99+/-8.98 fT/cm, respectively, and the mean laterality index, expressed by [(left-right)/(left+right)] was 0.025+/-0.104. This parameter can be useful for evaluating patients with unilateral sensory abnormality of the tongue.
舌感觉障碍的定量评估在临床上具有重要意义。然而，由于舌神经走行较深，传统的外周神经电生理方法无法用于下颌骨，因此我们采用中枢神经系统诱发电位。通过将针电极置于舌黏膜上，记录了10名健康受试者在电刺激后的体感诱发磁场（SEF）。单侧刺激时，在对侧半球可识别出三或四个成分（P25m、P40m、P60m和P80m）。由于并非所有受试者都能一致检测到这些成分，我们评估了对侧半球18个通道的均方根（RMS）。为了估计激活的皮质反应，我们计算了10至150毫秒之间的平均RMS振幅与基线期（aRMS = RMS[10, 150] - RMS[-50, -5]）的差异。右侧和左侧刺激的aRMS值分别为10.18±7.92和10.99±8.98 fT/cm，以[(左 - 右)/(左 + 右)]表示的平均偏侧指数为0.025±0.104。该参数可用于评估单侧舌感觉异常的患者。
