细胞因子信号转导抑制因子对JAK/STAT信号通路的调控。
SOCS regulation of the JAK/STAT signalling pathway.
作者信息
Croker Ben A, Kiu Hiu, Nicholson Sandra E
机构信息
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Australia.
出版信息
Semin Cell Dev Biol. 2008 Aug;19(4):414-22. doi: 10.1016/j.semcdb.2008.07.010. Epub 2008 Jul 30.
Abstract
The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first described as inhibitors of cytokine signalling. While their actions clearly now extend to other intracellular pathways, they remain key negative regulators of cytokine and growth factor signalling. In this review we focus on the mechanics of SOCS action and the complexities of the mouse models that have underpinned our current understanding of SOCS biology.
摘要
细胞因子信号转导抑制因子（SOCS）蛋白，顾名思义，最初被描述为细胞因子信号转导的抑制剂。虽然它们的作用现在显然已扩展到其他细胞内途径，但它们仍然是细胞因子和生长因子信号转导的关键负调节因子。在这篇综述中，我们重点关注SOCS作用的机制以及支撑我们目前对SOCS生物学理解的小鼠模型的复杂性。
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