一些带有二苯砜基团的三唑曼尼希碱的合成、表征及抗菌活性
Synthesis, characterization and antibacterial activity of some triazole Mannich bases carrying diphenylsulfone moieties.
作者信息
Almajan Gabriela Laura, Barbuceanu Stefania-Felicia, Almajan Eva-Ruxandra, Draghici Constantin, Saramet Gabriel
机构信息
Organic Chemistry Department, Faculty of Pharmacy, Bucharest, Romania.
出版信息
Eur J Med Chem. 2009 Jul;44(7):3083-9. doi: 10.1016/j.ejmech.2008.07.003. Epub 2008 Jul 12.
A series of Mannich bases of 4-substituted 5-[4-(4-X-phenylsulfonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thiones, X=H, Cl, Br, 3 and 5 were synthesized and characterized on the basis of IR, NMR and elemental analyses. The potential antibacterial effects of the synthesized compounds were investigated using the Acinetobacter baumanii ATCC 19606; Citrobacter freundii ATCC 8090; Pseudomonas aeruginosa ATCC 9027; Enterococcus faecalis ATCC 19433; Staphylococcus aureus ATCC 12600; Staphylococcus epidermidis ATCC 14990; Bacillus subtilis ATCC 6633 strains. Some of them exhibited promising activities against A. baumanii and B. subtilis.
合成了一系列4-取代的5-[4-(4-X-苯基磺酰基)苯基]-2,4-二氢-3H-1,2,4-三唑-3-硫酮的曼尼希碱，其中X = H、Cl、Br、3和5，并通过红外光谱、核磁共振和元素分析对其进行了表征。使用鲍曼不动杆菌ATCC 19606、弗氏柠檬酸杆菌ATCC 8090、铜绿假单胞菌ATCC 9027、粪肠球菌ATCC 19433、金黄色葡萄球菌ATCC 12600、表皮葡萄球菌ATCC 14990、枯草芽孢杆菌ATCC 6633菌株研究了合成化合物的潜在抗菌作用。其中一些化合物对鲍曼不动杆菌和枯草芽孢杆菌表现出有前景的活性。
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