Wang Hongbo, Zhu Hui, Fu Weigui, Zhang Yinyu, Xu Bing, Gao Fei, Cao Zhiqiang, Liu Wenguang
School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300072, China.
Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, 48202, USA.
Macromol Rapid Commun. 2017 May;38(9). doi: 10.1002/marc.201600695. Epub 2017 Mar 8.
There is a significant cost to mitigate the infection and inflammation associated with the implantable medical devices. The development of effective antibacterial and anti-inflammatory biomaterials with novel mechanism of action has become an urgent task. In this study, a supramolecular polymer hydrogel is synthesized by the copolymerization of N-acryloyl glycinamide and 1-vinyl-1,2,4-triazole in the absence of any chemical crosslinker. The hydrogel network is crosslinked through the hydrogen bond interactions between dual amide motifs in the side chain of N-acryloyl glycinamide. The prepared hydrogels demonstrate excellent mechanical properties-high tensile strength (≈1.2 MPa), large stretchability (≈1300%), and outstanding compressive strength (≈11 MPa) at swelling equilibrium state. A simulation study elaborates the changes of hydrogen bond interactions when 1-vinyl-1,2,4-triazole is introduced into the gel network. It is demonstrated that the introduction of 1-vinyl-1,2,4-triazole endowes the supramolecular hydrogels with self-repairability, thermoplasticity, and reprocessability over a lower temperature range for 3D printing of different shapes and patterns under simplified thermomelting extrusion condition. In addition, these hydrogels exhibit antimicrobial and anti-inflammatory activities, and in vitro cytotoxicity assay and histological staining following in vivo implantation confirm the biocompatibility of the hydrogel. These hydrogels with integrated multifunctions hold promising potential as an injectable biomaterial for treating degenerated soft supporting tissues.
减轻与可植入医疗设备相关的感染和炎症存在巨大成本。开发具有新型作用机制的有效抗菌和抗炎生物材料已成为一项紧迫任务。在本研究中，通过N-丙烯酰甘氨酰胺和1-乙烯基-1,2,4-三唑在无任何化学交联剂的情况下共聚合成了一种超分子聚合物水凝胶。水凝胶网络通过N-丙烯酰甘氨酰胺侧链中双酰胺基序之间的氢键相互作用交联。所制备的水凝胶在溶胀平衡状态下表现出优异的机械性能——高拉伸强度（≈1.2 MPa）、大拉伸性（≈1300%）和出色的抗压强度（≈11 MPa）。一项模拟研究阐述了将1-乙烯基-1,2,4-三唑引入凝胶网络时氢键相互作用的变化。结果表明，1-乙烯基-1,2,4-三唑的引入赋予超分子水凝胶在较低温度范围内具有自修复性、热塑性和可再加工性，以便在简化的热熔挤出条件下进行不同形状和图案的3D打印。此外，这些水凝胶具有抗菌和抗炎活性，体外细胞毒性试验和体内植入后的组织学染色证实了水凝胶的生物相容性。这些具有集成多功能的水凝胶作为治疗退化软支撑组织的可注射生物材料具有广阔的应用前景。
