Chugh Dipankar, Kaler Karan V I S
Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada.
Biomed Mater. 2008 Sep;3(3):034009. doi: 10.1088/1748-6041/3/3/034009. Epub 2008 Aug 15.
Miniaturized fluidic systems have been developed in recent years and offer new and novel means of leveraging the domain of microfluidics for the development of micro-total analysis systems (microTAS). Initially, such systems employed closed microchannels in order to facilitate chip-based biochemical assays, requiring very small quantities of sample and/or reagents and furthermore providing rapid and low-cost analysis on a compact footprint. More recently, advancements in the domain of surface microfluidics have suggested that similar low volume sample handling and manipulation capabilities for bioassays can be attained by leveraging the phenomena of liquid dielectrophoresis and droplet dielectrophoresis (DEP), without the need for separate pumps or valves. Some of the key aspects of this surface microfluidic technology and its capabilities are discussed and highlighted in this paper. We, furthermore, examine the integration and utility of liquid DEP and droplet DEP in providing rapid and automated sample handling and manipulation capabilities on a compact chip-based platform.
近年来，微型流体系统得到了发展，为利用微流体领域开发微全分析系统（μTAS）提供了新的手段。最初，此类系统采用封闭的微通道，以促进基于芯片的生化分析，所需样品和/或试剂的量非常少，而且能在紧凑的空间内实现快速、低成本分析。最近，表面微流体领域的进展表明，通过利用液体介电电泳和液滴介电电泳（DEP）现象，无需单独的泵或阀门，就可以实现类似的用于生物分析的低体积样品处理和操作能力。本文讨论并强调了这种表面微流体技术的一些关键方面及其能力。此外，我们研究了液体DEP和液滴DEP在基于芯片的紧凑平台上提供快速、自动化样品处理和操作能力方面的集成和实用性。
