Hellström S, Goldie P
Department of Otorhinolaryngology, University of Umeå, Sweden.
Otolaryngol Clin North Am. 1991 Aug;24(4):829-34.
The mucosal lining of the middle ear cavity, in particular that of the tympanic membrane and its pars flaccida, exhibits a number of sensory nerves containing the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP). The mucosa is not only rich in nerves and blood vessels but also contains numerous mast cells. It is possible that interactions between histamine-containing mast cells and SP-containing and CGRP-containing nerves--neurogenic inflammation--is one of the mechanisms involved in vessel permeability changes in otitis media with effusion.
中耳腔的黏膜内衬，尤其是鼓膜及其松弛部的黏膜内衬，呈现出许多含有神经肽P物质（SP）和降钙素基因相关肽（CGRP）的感觉神经。该黏膜不仅富含神经和血管，还含有大量肥大细胞。含组胺的肥大细胞与含SP和含CGRP的神经之间的相互作用——神经源性炎症——可能是分泌性中耳炎血管通透性改变所涉及的机制之一。
