Yelnik A, Dizien O, Bussel B, Schouman-Claeys E, Frija G, Pannier S, Held J P
Service de Rééducation Neurologique, Hôpital Raymond Poincaré, Garches, France.
Paraplegia. 1991 May;29(4):253-60. doi: 10.1038/sc.1991.36.
This study was concluded on paraplegic and tetraplegic patients of all aetiologies except neoplasic, where paralysis developed within 48 hours. All patients were admitted to the rehabilitation department within 90 days after the onset of paralysis. In a preliminary review of 328 files, there were 27 cases of clinical deep vein thrombosis (DVT) and 10 with pulmonary embolism (PE), 6 of which were fatal. A prospective study was conducted, based on systematic detection of asymptomatic DVT with phlebography. Among the 147 patients, 20 previously presented with DVT. The 127 others underwent phlebography which showed 39 DVT in 29 patients. Eighty seven patients with negative phlebography underwent a second study a month later which showed 14 DVT in 12 patients. Only one minor pulmonary embolism occurred in these 147 patients. The incidence of DVT after acute spinal cord injury and the frequent absence of clinical manifestations were confirmed. Prophylactic anticoagulant therapy is useful but insufficient. This study demonstrates that systematic and repeated detection of DVT by phlebography may reduce the incidence of PE.
本研究纳入了所有病因(肿瘤除外)导致的截瘫和四肢瘫患者,这些患者在48小时内出现瘫痪。所有患者在瘫痪发作后90天内入住康复科。在对328份病历的初步审查中,有27例临床诊断为深静脉血栓形成(DVT),10例有肺栓塞(PE),其中6例死亡。基于通过静脉造影对无症状DVT进行系统检测开展了一项前瞻性研究。在147例患者中,20例既往有DVT病史。其他127例患者接受了静脉造影,结果显示29例患者中有39处DVT。87例静脉造影阴性的患者在一个月后进行了二次检查,结果显示12例患者中有14处DVT。在这147例患者中仅发生1例轻微肺栓塞。急性脊髓损伤后DVT的发生率以及临床表现的频繁缺失得到了证实。预防性抗凝治疗是有用的,但并不充分。本研究表明,通过静脉造影系统且重复地检测DVT可降低PE的发生率。