Padiyar Aparna, Akoum Fadi H, Hricik Donald E
Division of Nephrology, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Prim Care. 2008 Sep;35(3):433-50, v. doi: 10.1016/j.pop.2008.03.003.
The short-term outcomes of kidney transplant recipients have improved dramatically in the past 20 years, in large part resulting from the availability of more potent immunosuppressive drugs capable of preventing or treating acute allograft rejection. Ironically, side effects from these same immunosuppressants play a role in the long-term morbidity and mortality of this patient population. As kidney transplant recipients survive for longer periods of time with functioning allografts, primary care physicians will likely become more involved in their management, mandating at least a basic understanding of immunosuppression and its complications.
在过去20年里,肾移植受者的短期预后有了显著改善,这在很大程度上得益于有更多强效免疫抑制药物可供使用,这些药物能够预防或治疗急性移植肾排斥反应。具有讽刺意味的是,同样这些免疫抑制剂的副作用在该患者群体的长期发病率和死亡率中也起到了作用。随着肾移植受者依靠功能良好的移植肾存活更长时间,初级保健医生可能会更多地参与到他们的管理中,这就要求至少对免疫抑制及其并发症有基本的了解。