Thelen Marcus, Stein Jens V
Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland.
Nat Immunol. 2008 Sep;9(9):953-9. doi: 10.1038/ni.f.207.
A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here we summarize recent findings on the initial steps in chemokine receptor-induced signal transduction in leukocytes. In particular, we discuss the potential influences of the formation of oligomers of ligand and receptor and of coupling between chemokine signals and regulators of the cytoskeleton, such as small GTPases.
趋化因子系统的一个重要活动是对白细胞迁移的调节。在此，我们总结了关于趋化因子受体诱导白细胞信号转导初始步骤的最新研究发现。特别地，我们讨论了配体与受体寡聚体形成以及趋化因子信号与细胞骨架调节因子（如小GTP酶）之间偶联的潜在影响。
