Schyman Patric, Laaksonen Aatto
Division of Physical Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden.
J Am Chem Soc. 2008 Sep 17;130(37):12254-5. doi: 10.1021/ja805000g. Epub 2008 Aug 21.
In this theoretical study we have investigated the effect of low-energy electrons attached onto a 3'-guanine monophosphate, 3'-GMP, in the gas phase and in aqueous solution. DFT calculations with B3LYP/DZP++ were performed to study the C3'-O3' bond break of a 3'-GMP radical anion. Our results show that low-energy electrons, if attached to a 3'-GMP with a neutrally charged phosphate group, can easily induce a C3'-3' bond break in both the gas phase and aqueous solution. The activation energy was found here to be 10.3 kcal/mol in the gas phase and, even lower, 5.3 kcal/mol in aqueous solution. In comparison with calculated activation energies for other nucleotides the 3'-GMP has the lowest energy barrier in aqueous solution.
