2型糖尿病患者血清色素上皮衍生因子水平升高。
Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients.
作者信息
Jenkins Alicia, Zhang Sarah X, Gosmanova Albina, Aston Christopher, Dashti Azar, Baker Mary Zoe, Lyons Timothy, Ma Jian-Xing
机构信息
Department of Medicine, Endocrinology, Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
出版信息
Diabetes Res Clin Pract. 2008 Oct;82(1):e5-7. doi: 10.1016/j.diabres.2008.06.019. Epub 2008 Aug 19.
Abstract
Serum PEDF levels (mean (S.D.)) were increased in 96 Type 2 diabetic vs. 54 non-diabetic subjects; 5.3 (2.8) vs. 3.2 (2.0)mug/ml, p<0.001. In diabetes, PEDF correlated with BMI, serum creatinine and LDL-cholesterol, but not with other lipids, HbA1c or CRP. PEDF did not differ by drugs, complications, or gender.
摘要
96名2型糖尿病患者的血清色素上皮衍生因子（PEDF）水平（均值（标准差））升高，而54名非糖尿病受试者则未升高；分别为5.3（2.8）与3.2（2.0）微克/毫升，p<0.001。在糖尿病患者中，PEDF与体重指数、血清肌酐和低密度脂蛋白胆固醇相关，但与其他血脂、糖化血红蛋白或C反应蛋白无关。PEDF在药物、并发症或性别方面无差异。
相似文献
1
Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients.2型糖尿病患者血清色素上皮衍生因子水平升高。
Diabetes Res Clin Pract. 2008 Oct;82(1):e5-7. doi: 10.1016/j.diabres.2008.06.019. Epub 2008 Aug 19.
2
Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes.血清色素上皮衍生因子升高与1型糖尿病的微血管并发症、血管僵硬及炎症相关。
Diabet Med. 2007 Dec;24(12):1345-51. doi: 10.1111/j.1464-5491.2007.02281.x. Epub 2007 Oct 29.
3
[Change and significance of serum pigment epithelium-derived factor in type 2 diabetic nephropathy].[2型糖尿病肾病患者血清色素上皮衍生因子的变化及意义]
Zhonghua Yi Xue Za Zhi. 2007 May 15;87(18):1230-3.
4
Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome.血清色素上皮衍生因子与多囊卵巢综合征妇女高敏 C 反应蛋白的相关性。
J Endocrinol Invest. 2013 Sep;36(8):632-5. doi: 10.1007/BF03346755.
5
Elevated plasma pigment epithelium-derived factor in children with type 2 diabetes mellitus is attributable to obesity.2型糖尿病患儿血浆色素上皮衍生因子升高归因于肥胖。
Pediatr Diabetes. 2015 Dec;16(8):600-5. doi: 10.1111/pedi.12226. Epub 2014 Oct 8.
6
Pigment epithelium-derived factor increases in type 2 diabetes after treatment with metformin.二甲双胍治疗后 2 型糖尿病患者色素上皮衍生因子增加。
Clin Endocrinol (Oxf). 2012 Dec;77(6):852-6. doi: 10.1111/j.1365-2265.2012.04341.x.
7
Serum levels of pigment epithelium-derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes.在日本2型糖尿病患者中，血清色素上皮衍生因子（PEDF）水平与内脏肥胖呈正相关。
Diabetes Metab Res Rev. 2009 Jan;25(1):52-6. doi: 10.1002/dmrr.820.
8
The effects of calcium channel blockers on nephropathy and pigment epithelium-derived factor in the treatment of hypertensive patients with type 2 diabetes mellitus.钙通道阻滞剂对 2 型糖尿病高血压患者肾病及色素上皮衍生因子的影响。
Clin Exp Hypertens. 2015;37(3):177-83. doi: 10.3109/10641963.2014.933964. Epub 2014 Jul 22.
9
Diabetic nephropathy: serum miR-9 confers a poor prognosis in and is associated with level changes of vascular endothelial growth factor and pigment epithelium-derived factor.糖尿病肾病：血清miR-9预示预后不良且与血管内皮生长因子和色素上皮衍生因子水平变化相关。
Biotechnol Lett. 2017 Oct;39(10):1583-1590. doi: 10.1007/s10529-017-2390-6. Epub 2017 Jun 30.
10
Pigment Epithelium-Derived Factor Declines in Response to an Oral Glucose Load and Is Correlated with Vitamin D and BMI but Not Diabetes Status in Children and Young Adults.色素上皮衍生因子对口服葡萄糖负荷产生反应而下降，且与儿童和年轻成人的维生素D及体重指数相关，但与糖尿病状态无关。
Horm Res Paediatr. 2017;87(5):301-306. doi: 10.1159/000466692. Epub 2017 Apr 11.
引用本文的文献
1
PEDF and Its Role in Metabolic Disease, Angiogenesis, Cardiovascular Disease, and Diabetes.色素上皮衍生因子及其在代谢性疾病、血管生成、心血管疾病和糖尿病中的作用。
Biomedicines. 2025 Jul 21;13(7):1780. doi: 10.3390/biomedicines13071780.
2
Acute Stress and Autoimmune Markers: Evaluating the Psychoneuroimmunology Axis in Firefighter Recruits.急性应激与自身免疫标志物：评估消防员新兵的心理神经免疫学轴
Int J Mol Sci. 2025 Apr 22;26(9):3945. doi: 10.3390/ijms26093945.
3
Glucose Variability is Independently Correlated with Serum Level of Pigment Epithelium-Derived Factor in Type 2 Diabetes.2型糖尿病患者的血糖变异性与色素上皮衍生因子血清水平独立相关。
Diabetes Ther. 2021 Mar;12(3):827-842. doi: 10.1007/s13300-021-01008-y. Epub 2021 Feb 13.
4
Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake.骨骼肌在胰岛素抵抗和葡萄糖摄取中的作用。
Compr Physiol. 2020 Jul 8;10(3):785-809. doi: 10.1002/cphy.c190029.
5
C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients with Gestational Diabetes Mellitus: A Case-Control Study.妊娠糖尿病患者中C1q/TNF相关蛋白-3（CTRP-3）和色素上皮衍生因子（PEDF）的浓度：一项病例对照研究
J Clin Med. 2020 Aug 10;9(8):2587. doi: 10.3390/jcm9082587.
6
Serum pigment epithelium-derived factor: Relationships with cardiovascular events, renal dysfunction, and mortality in the Veterans Affairs Diabetes Trial (VADT) cohort.血清色素上皮衍生因子：退伍军人事务糖尿病试验 (VADT) 队列中心血管事件、肾功能障碍和死亡率的关系。
J Diabetes Complications. 2019 Oct;33(10):107410. doi: 10.1016/j.jdiacomp.2019.107410. Epub 2019 Jul 26.
7
Increased levels of serum pigment epithelium-derived factor aggravate proteinuria via induction of podocyte actin rearrangement.血清色素上皮衍生因子水平升高通过诱导足细胞肌动蛋白重排加重蛋白尿。
Int Urol Nephrol. 2019 Feb;51(2):359-367. doi: 10.1007/s11255-018-2026-3. Epub 2018 Dec 7.
8
Pulmonary vascular dysfunction in metabolic syndrome.代谢综合征中的肺血管功能障碍。
J Physiol. 2019 Feb;597(4):1121-1141. doi: 10.1113/JP275856. Epub 2018 Sep 12.
9
Pigment Epithelium-Derived Factor Declines in Response to an Oral Glucose Load and Is Correlated with Vitamin D and BMI but Not Diabetes Status in Children and Young Adults.色素上皮衍生因子对口服葡萄糖负荷产生反应而下降，且与儿童和年轻成人的维生素D及体重指数相关，但与糖尿病状态无关。
Horm Res Paediatr. 2017;87(5):301-306. doi: 10.1159/000466692. Epub 2017 Apr 11.
10
Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications.糖尿病视网膜病变中的神经血管相互作用：病理生理作用及治疗意义
Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H738-49. doi: 10.1152/ajpheart.00005.2016. Epub 2016 Jul 29.
本文引用的文献
1
Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes.血清色素上皮衍生因子升高与1型糖尿病的微血管并发症、血管僵硬及炎症相关。
Diabet Med. 2007 Dec;24(12):1345-51. doi: 10.1111/j.1464-5491.2007.02281.x. Epub 2007 Oct 29.
2
[Change and significance of serum pigment epithelium-derived factor in type 2 diabetic nephropathy].[2型糖尿病肾病患者血清色素上皮衍生因子的变化及意义]
Zhonghua Yi Xue Za Zhi. 2007 May 15;87(18):1230-3.
3
Plasma concentration of pigment epithelium-derived factor in patients with diabetic retinopathy.糖尿病视网膜病变患者色素上皮衍生因子的血浆浓度
J Clin Endocrinol Metab. 2007 Mar;92(3):1176-9. doi: 10.1210/jc.2006-2249. Epub 2007 Jan 9.
4
Increased serum concentrations of pigment epithelium-derived factor in patients with end-stage renal disease.终末期肾病患者血清色素上皮衍生因子浓度升高。
Clin Chem. 2006 Oct;52(10):1970-1. doi: 10.1373/clinchem.2006.073171.
5
Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy.色素上皮衍生因子下调血管内皮生长因子（VEGF）的表达，并抑制糖尿病视网膜病变中VEGF与VEGF受体2的结合。
J Mol Endocrinol. 2006 Aug;37(1):1-12. doi: 10.1677/jme.1.02008.
6
Salutary effect of pigment epithelium-derived factor in diabetic nephropathy: evidence for antifibrogenic activities.色素上皮衍生因子在糖尿病肾病中的有益作用：抗纤维化活性的证据
Diabetes. 2006 Jun;55(6):1678-85. doi: 10.2337/db05-1448.
7
Elevated serum levels of pigment epithelium-derived factor in the metabolic syndrome.代谢综合征中色素上皮衍生因子血清水平升高。
J Clin Endocrinol Metab. 2006 Jun;91(6):2447-50. doi: 10.1210/jc.2005-2654. Epub 2006 Mar 7.
8
Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor.色素上皮衍生因子（PEDF）是一种内源性抗炎因子。
FASEB J. 2006 Feb;20(2):323-5. doi: 10.1096/fj.05-4313fje. Epub 2005 Dec 20.
9
Decreased expression of pigment epithelium-derived factor is involved in the pathogenesis of diabetic nephropathy.色素上皮衍生因子表达降低参与糖尿病肾病的发病机制。
Diabetes. 2005 Jan;54(1):243-50. doi: 10.2337/diabetes.54.1.243.
10
PEDF: a multifaceted neurotrophic factor.色素上皮衍生因子：一种多方面的神经营养因子。
Nat Rev Neurosci. 2003 Aug;4(8):628-36. doi: 10.1038/nrn1176.
Zotero 插件