Maier K P
Leberzentrum, Klinikum Esslingen, Akademisches Lehrkrankenhaus der Universität Tübingen.
Praxis (Bern 1994). 2008 Jul 9;97(14):772-8. doi: 10.1024/1661-8157.97.14.772.
Ascites means accumulation of fluid within the peritoneal cavity, usually in patients with cirrhosis. Diagnostic paracentesis (cell count, albumin, cell culture) is a must. Na-restriction remains the cornerstone of treatment (< 3 g NaCl/d). Spironolactone is the drug of choice, in some patients in addition with proximally acting diuretics. Minimum effective dosage is recommented to reduce side-effects. Pronounced ascites can be treated by large-volume paracentesis with concomitant albumin-infusion. Only very few patients suffer from refractory ascites. TIPS is a treatment modality for this group. However, TIPS may precipitate PSE in some patients with decompensated liver cirrhosis.
腹水是指腹腔内液体的积聚,通常发生在肝硬化患者中。诊断性腹腔穿刺术(细胞计数、白蛋白、细胞培养)是必要的。限制钠摄入仍然是治疗的基石(<3克氯化钠/天)。螺内酯是首选药物,部分患者可加用近端作用利尿剂。建议使用最小有效剂量以减少副作用。大量腹水可通过大量腹腔穿刺术并同时输注白蛋白进行治疗。只有极少数患者会出现顽固性腹水。经颈静脉肝内门体分流术(TIPS)是针对这一群体的一种治疗方式。然而,TIPS可能会在一些失代偿期肝硬化患者中诱发肝性脑病(PSE)。