Guihard S, Noël G
Centre de lutte contre le cancer, Paul Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France.
Cancer Radiother. 2009 Jan;13(1):47-54. doi: 10.1016/j.canrad.2008.06.006. Epub 2008 Aug 20.
Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin with features of epithelial differentiation. It occurs in older patients, appears on sun exposed areas and its incidence is increasing. The surgical excision with negative margins is the first treatment and adjuvant local irradiation now is well established but regional adjuvant (lymph nodes dissection or radiation therapy) remains discussed. MCC is chemosensitive but rarely chemocurable in patients with metastasis or locally advanced tumors. The most used therapy is platinum-based polychemotherapy.
默克尔细胞癌（MCC）是一种罕见的皮肤神经内分泌癌，具有上皮分化特征。它发生于老年患者，出现在阳光暴露部位，且发病率正在上升。手术切缘阴性的手术切除是首要治疗方法，目前辅助局部放疗已得到广泛认可，但区域辅助治疗（淋巴结清扫或放射治疗）仍存在争议。MCC对化疗敏感，但对于有转移或局部晚期肿瘤的患者很少能通过化疗治愈。最常用的治疗方法是铂类联合化疗。
