5'单磷酸腺苷激活蛋白激酶在骨骼肌中的作用。

Role of 5'AMP-activated protein kinase in skeletal muscle.

作者信息

Treebak J T, Wojtaszewski J F P

机构信息

Molecular Physiology Group, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

Int J Obes (Lond). 2008 Sep;32 Suppl 4:S13-7. doi: 10.1038/ijo.2008.117.

DOI:10.1038/ijo.2008.117

PMID:18719592

Abstract

5'AMP-activated protein kinase (AMPK) is recognized as an important intracellular energy sensor, shutting down energy-consuming processes and turning on energy-generating processes. Discovery of target proteins of AMPK has dramatically increased in the past 10 years. Historically, AMPK was first shown to regulate fatty acid and cholesterol synthesis, but is now hypothesized to take part in the regulation of energy/fuel balance not only at the cellular level but also at the level of the whole organism. In this brief review we will discuss some of the roles of AMPK in skeletal muscle.

摘要

5'-腺苷酸激活蛋白激酶（AMPK）被认为是一种重要的细胞内能量传感器，它会关闭耗能过程并开启产能过程。在过去十年中，AMPK靶蛋白的发现急剧增加。从历史上看，AMPK最初被证明可调节脂肪酸和胆固醇的合成，但现在推测它不仅在细胞水平而且在整个生物体水平参与能量/燃料平衡的调节。在这篇简短的综述中，我们将讨论AMPK在骨骼肌中的一些作用。