Laboratory of Clinical Pathology, IRCCS S. De Bellis, National Institute for Digestive Disease, Castellana, Bari, Italy.
Immunopharmacol Immunotoxicol. 2008;30(4):925-36. doi: 10.1080/08923970802337718.
Glycated apolipoprotein B (ApoB-G), a non enzymatically glycated protein, has recently been associated with myocardial infarction. Our aim is to evaluate, in diabetic and non diabetic subjects, the relationship of ApoB-G with serum fasting glucose, fructosamine, stable and labile fractions of glycated hemoglobin ((S)HbA(1c), (L)HbA(1c), respectively) and insulin. The subjects were recruited from a previous study on ApoB-G and myocardial infarction: 141 of them were studied, 43 with and 98 without diabetes. ApoB-G was measured using a monoclonal antibody, and linear regression and correlation were used for statistical analysis of the data. ApoB-G was higher in diabetic than in non diabetic subjects. There was a statistically significant correlation of ApoB-G with triglycerides (r = 0.38, p = 0.01) in diabetic subjects, and with total proteins (r = 0.37, p = 0.0002), triglycerides (r = 0.34, p = 0.0007), and cholesterol (r = 0.23, p = 0.02) in non diabetic subjects. In the most parsimonious multiple linear regression model of ApoB-G on all the other serum variables, there was a statistically significant association of ApoB-G with triglycerides, in both diabetic and non diabetic subjects. The main results of this study suggest that serum ApoB-G is associated with serum triglycerides in both diabetic and non diabetic subjects.
糖化载脂蛋白 B（ApoB-G），一种非酶糖化蛋白，最近与心肌梗死有关。我们的目的是在糖尿病和非糖尿病患者中评估 ApoB-G 与血清空腹血糖、果糖胺、糖化血红蛋白的稳定和不稳定部分（（S）HbA（1c）、（L）HbA（1c））以及胰岛素的关系。这些受试者是从之前关于 ApoB-G 和心肌梗死的研究中招募的：其中 141 人接受了研究，43 人患有糖尿病，98 人没有糖尿病。使用单克隆抗体测量 ApoB-G，并使用线性回归和相关性对数据进行统计分析。糖尿病患者的 ApoB-G 高于非糖尿病患者。在糖尿病患者中，ApoB-G 与甘油三酯呈显著正相关（r = 0.38，p = 0.01），在非糖尿病患者中，与总蛋白（r = 0.37，p = 0.0002）、甘油三酯（r = 0.34，p = 0.0007）和胆固醇（r = 0.23，p = 0.02）呈显著正相关。在 ApoB-G 对所有其他血清变量的最简约多元线性回归模型中，在糖尿病和非糖尿病患者中，ApoB-G 与甘油三酯均呈显著相关。本研究的主要结果表明，血清 ApoB-G 与糖尿病和非糖尿病患者的血清甘油三酯有关。
