[Characteristics of a vasomotor endothelial function of the major and cerebral arteries in bronchial asthma].

We investigated endothelium dependent and independent activity of major and cerebral arteries in mice with experimental bronchial asthma. Regional features of endothelium dependent reactions of arteries were established. It was found that the carotid artery has greater vasomotor activity than the medial cerebral artery. Development of experimental bronchial asthma is associated with sharp reduction of reserve ability for endothelium independent dilatation against intensification of endothelium dependent dilatation; enhancement of constrictor effects of vascular endothelium in major and attenuation in cerebral compartments.