Trémeau Fabien, Goggin Michelle, Antonius Daniel, Czobor Pàl, Hill Vera, Citrome Leslie
Clinical Research and Evaluation Facility, Nathan S. Kline Institute for Psychiatric Research and Rockland Psychiatric Center, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
Psychiatry Res. 2008 Sep 30;160(3):346-55. doi: 10.1016/j.psychres.2007.06.021. Epub 2008 Aug 22.
The commonly used rating scales for negative symptoms in schizophrenia have shown good reliability, but disagreement persists regarding both the content definition and the validity of several items. Instead, authors have recommended rating the specific behaviors that are defined as negative symptoms. To surmount these shortcomings, we developed a new rating scale for negative symptoms: the Motor-Affective-Social Scale (MASS). During a 5-minute structured interview, hand coverbal gestures, spontaneous smiles, voluntary smiling, and questions asked by the interviewer were counted and rated on 101 inpatients with a diagnosis of schizophrenia or schizoaffective disorder. Information on social behavior was obtained from nursing staff. The scale consisted of a total of eight items. The MASS showed high internal consistency (Cronbach alpha coefficient=0.81), inter-rater reliability, and test-retest reliability (intra-class correlation coefficient=0.81). Convergent validity analyses showed high correlations between MASS scores and scores on the Scale for the Assessment of Negative Symptom (SANS), and the negative symptoms subscale of the Positive and Negative Syndrome Scale (PANSS). The MASS showed excellent psychometric properties, practicality, and subject tolerability. Future research that includes the use of the MASS with other patient populations and that investigates the scale's sensitivity during clinical trials should be performed.
精神分裂症阴性症状常用的评定量表已显示出良好的信度,但在内容定义和几个条目的效度方面仍存在分歧。相反,作者建议对定义为阴性症状的特定行为进行评定。为克服这些缺点,我们开发了一种新的阴性症状评定量表:运动-情感-社交量表(MASS)。在一次5分钟的结构化访谈中,对101例诊断为精神分裂症或分裂情感性障碍的住院患者的手部覆盖性手势、自发微笑、主动微笑以及访谈者提出的问题进行计数和评分。社会行为信息来自护理人员。该量表共有八个条目。MASS显示出高内部一致性(克朗巴赫α系数=0.81)、评分者间信度和重测信度(组内相关系数=0.81)。收敛效度分析显示,MASS得分与阴性症状评定量表(SANS)得分以及阳性和阴性症状量表(PANSS)的阴性症状分量表得分之间存在高度相关性。MASS显示出优异的心理测量学特性、实用性和受试者耐受性。未来应开展研究,包括将MASS应用于其他患者群体,并在临床试验中研究该量表的敏感性。