Kuloğlu Zarife, Kansu Aydan, Kirsaçlioğlu Ceyda Tuna, Ustündağ Gonca, Aysev Derya, Ensari Arzu, Küçük Nuriye Ozlem, Girgin Nurten
Pediatric Gastroenterology, School of Medicine, Ankara University, 06100 Ankara, Turkey.
Diagn Microbiol Infect Dis. 2008 Dec;62(4):351-6. doi: 10.1016/j.diagmicrobio.2008.07.006. Epub 2008 Aug 21.
Our aim was to evaluate diagnostic accuracy of rapid immunochromatographic stool antigen test (Rapid HpSA; LINEAR Chemical, Barcelona, Spain) and a practical low-dose (14)C urea breath test (UBT) (Heliprobetrade mark) test before and after eradication therapy. One hundred nine children with abdominal symptoms (age range, 5-17 years; mean, 12.1) underwent endoscopy, (14)C-UBT, and Rapid HpSA. Patients were defined as Hp infected when histology was positive for Hp. Forty children (36.6%) were Hp infected. The sensitivity of Rapid HpSA and (14)C-UBT was 65% and 92.5% (P = 0.0003), respectively; the specificity of Rapid HpSA and (14)C-UBT was 92.3% and 85.5% (P = 0.180), respectively. After eradication therapy endoscopy, (14)C-UBT and Rapid HpSA were repeated. The eradication rate was 70.5%. After eradication, the sensitivity of Rapid HpSA and (14)C-UBT was 60% and 100%, respectively; the specificity of Rapid HpSA and (14)C-UBT was 100%. (14)C-UBT was more reliable than the Rapid HpSA test for the diagnosis and for confirming eradication of Hp infection.
我们的目的是评估快速免疫层析粪便抗原检测（Rapid HpSA；LINEAR Chemical，巴塞罗那，西班牙）以及实用的低剂量（14）C尿素呼气试验（UBT）（Heliprobetrade mark）在根除治疗前后的诊断准确性。109名有腹部症状的儿童（年龄范围5 - 17岁；平均12.1岁）接受了内镜检查、（14）C - UBT和Rapid HpSA检测。当组织学检查显示幽门螺杆菌（Hp）阳性时，患者被定义为Hp感染。40名儿童（36.6%）被诊断为Hp感染。Rapid HpSA和（14）C - UBT的敏感性分别为65%和92.5%（P = 0.0003）；Rapid HpSA和（14）C - UBT的特异性分别为92.3%和85.5%（P = 0.180）。在根除治疗后，再次进行内镜检查、（14）C - UBT和Rapid HpSA检测。根除率为70.5%。根除治疗后，Rapid HpSA和（14）C - UBT的敏感性分别为60%和100%；Rapid HpSA和（14）C - UBT的特异性均为100%。对于诊断和确认Hp感染的根除情况，（14）C - UBT比Rapid HpSA检测更可靠。
