Callaghan John J, Warth Lucian C, Hoballah Jamal J, Liu Steve S, Wells Christopher W
University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.
J Arthroplasty. 2008 Sep;23(6 Suppl 1):20-4. doi: 10.1016/j.arth.2008.05.018.
Our objective of the study was to address the question: "What is the efficacy of a deep venous thrombosis (DVT) and pulmonary embolus prophylaxis protocol after total knee arthroplasty (TKA) in which low-risk patients had only aspirin and mechanical devices for prophylaxis?" A multimodal approach to DVT prophylaxis using aspirin as the primary mode of chemoprophylaxis was successful in preventing DVT-related morbidity and mortality in 312 consecutive TKAs performed in low-risk patients. There were no DVT-related deaths and no deaths in general at 90 days of follow-up coupled with a low rate of readmission for thromboembolic events and no readmissions or reoperations from bleeding in this group. This low-morbidity, low-cost prophylaxis should be considered an appropriate protocol for low-risk patients undergoing TKA. Of all TKAs performed during the time period of the study, 73% qualified for the low-risk group.
“在全膝关节置换术（TKA）后，对于低风险患者仅采用阿司匹林和机械装置进行预防的深静脉血栓形成（DVT）和肺栓塞预防方案的效果如何？”在低风险患者连续进行的312例TKA手术中，采用以阿司匹林作为主要化学预防方式的多模式DVT预防方法成功预防了DVT相关的发病和死亡情况。在90天的随访期内，没有DVT相关死亡，总体上也没有死亡，同时血栓栓塞事件的再入院率较低，并且该组没有因出血导致的再次入院或再次手术情况。这种低发病率、低成本的预防措施应被视为低风险TKA患者的合适方案。在研究期间进行的所有TKA手术中，73%的患者符合低风险组标准。
