α-异硫氰酸酯亚胺与醛的催化对映选择性羟醛加成反应。
Catalytic enantioselective aldol additions of alpha-isothiocyanato imides to aldehydes.
作者信息
Li Le, Klauber Eric G, Seidel Daniel
机构信息
Department of Chemistry and Chemical Biology, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854, USA.
出版信息
J Am Chem Soc. 2008 Sep 17;130(37):12248-9. doi: 10.1021/ja804838y. Epub 2008 Aug 23.
PMID:18722434
Abstract
Highly enantioselective organocatalytic aldol additions of alpha-isothiocyanato imides to aldehydes are reported. These reactions provide convenient access to enantiomerically enriched and protected beta-hydroxy-alpha-amino acids with catalyst loadings as low as 1 mol%.
摘要
报道了α-异硫氰酸酯亚胺与醛的高度对映选择性有机催化羟醛加成反应。这些反应能以低至1 mol%的催化剂用量方便地获得对映体富集的和受保护的β-羟基-α-氨基酸。
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