Musonda Patrick, Hocine Mounia N, Andrews Nick J, Tubert-Bitter Pascale, Farrington C Paddy
Department of Mathematics and Statistics, The Open University, Milton Keynes, UK.
Vaccine. 2008 Oct 3;26(42):5358-67. doi: 10.1016/j.vaccine.2008.08.010. Epub 2008 Aug 22.
We adapt the self-controlled case series method for routine surveillance of vaccine safety using cumulative sum (CUSUM) charts. The CUSUM surveillance method we propose is applicable for detecting associations that arise in a short pre-determined risk period following vaccination. The performance of the case series CUSUM is investigated through simulations. We illustrate the method using retrospective analyses of influenza vaccine and Bell's palsy, and MMR vaccine and febrile convulsions.
我们采用自我对照病例系列方法，利用累积和（CUSUM）图表对疫苗安全性进行常规监测。我们提出的CUSUM监测方法适用于检测接种疫苗后在预先确定的短风险期内出现的关联。通过模拟研究了病例系列CUSUM的性能。我们通过对流感疫苗与贝尔麻痹、麻疹腮腺炎风疹疫苗与热性惊厥的回顾性分析来说明该方法。
