Bidet A, Marit G, Bérard A M
Service d'hématologie biologique, CHU de Bordeaux, Pessac.
Ann Biol Clin (Paris). 2008 Jul-Aug;66(4):427-31. doi: 10.1684/abc.2008.0250.
Monoclonal free light chains are found in the serum and urine of patients with B-cell proliferative disorders, including multiple myeloma. Measuring free light chains in serum is useful for the diagnosis and monitoring of free light chains diseases. Moreover it could be interesting in the monitoring of treated multiple myeloma with complete immunoglobulin and of monoclonal gammapathy of undetermined significance (MGUS). The goal of our work was to analyze a large cohort of patients with multiple myeloma or MGUS from January 2003 to August 2006 in order to better understand the interest of free light chains.
在包括多发性骨髓瘤在内的B细胞增殖性疾病患者的血清和尿液中可发现单克隆游离轻链。检测血清中的游离轻链有助于游离轻链疾病的诊断和监测。此外，在监测免疫球蛋白完全正常的多发性骨髓瘤治疗患者以及意义未明的单克隆丙种球蛋白病（MGUS）方面，它可能也具有重要意义。我们研究的目的是分析2003年1月至2006年8月期间一大群多发性骨髓瘤或MGUS患者，以便更好地了解游离轻链的作用。
