Mayo Mary M, Johns Gretchen Schaef
Department of Pathology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Contrib Nephrol. 2007;153:44-65. doi: 10.1159/000096760.
Serum free light chain assay is a recently available test for diagnosis and monitoring of patients with plasma cell dyscrasias. In particular, this test is especially useful in patients that were previously difficult to follow with traditional laboratory methods. These patients include non-secretory multiple myeloma, amyloidosis and light chain deposition disease. In addition other uses for the test include monitoring response to treatment and earlier detection of relapse in all patients with plasma cell dyscrasias. Potential uses include assessing progression of patients with monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, solitary bone plasmacytoma and extramedullary plasmacytoma to multiple meyloma. Analytical considerations for the assay are also discussed.
血清游离轻链检测是一种最近可用于诊断和监测浆细胞异常增生患者的检测方法。特别是，该检测对于以前难以用传统实验室方法进行跟踪的患者尤其有用。这些患者包括非分泌型多发性骨髓瘤、淀粉样变性和轻链沉积病。此外，该检测的其他用途包括监测所有浆细胞异常增生患者的治疗反应和更早地检测复发。潜在用途包括评估意义未明的单克隆丙种球蛋白病、冒烟型多发性骨髓瘤、孤立性骨浆细胞瘤和髓外浆细胞瘤患者进展为多发性骨髓瘤的情况。还讨论了该检测的分析注意事项。
