1型糖尿病的免疫疗法。
Immunotherapy of type 1 diabetes.
作者信息
Li Li, Yi Zuoan, Tisch Roland, Wang Bo
机构信息
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA.
出版信息
Arch Immunol Ther Exp (Warsz). 2008 Jul-Aug;56(4):227-36. doi: 10.1007/s00005-008-0025-2. Epub 2008 Jul 29.
Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing beta cells are destroyed. Diabetic patients manage their hyperglycemia by daily insulin injections. However, insulin therapy is by no means a cure. Accordingly, a significant effort has been ongoing to develop immunotherapies that effectively prevent and/or treat T1D in the clinic. This review focuses on antigen- and antibody-based immunotherapies and discusses the respective strengths and weaknesses of these approaches.
1型糖尿病（T1D）是一种自身免疫性疾病，其中产生胰岛素的β细胞被破坏。糖尿病患者通过每日注射胰岛素来控制高血糖。然而，胰岛素治疗绝不是一种治愈方法。因此，一直在进行大量努力来开发能够在临床上有效预防和/或治疗T1D的免疫疗法。本综述重点关注基于抗原和抗体的免疫疗法，并讨论这些方法各自的优缺点。
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