Roberts R M
Department of Animal Sciences and Biochemistry, College of Agriculture, University of Missouri-Columbia 65211.
Bioessays. 1991 Mar;13(3):121-6. doi: 10.1002/bies.950130305.
In order to survive, the developing conceptus must interrupt the normal ovarian cycle of the mother and extend the production of progesterone by the corpus luteum. An unusual Type 1 interferon (IFN), related structurally to the IFN-alpha molecule and produced in massive amounts for only a few days by the first epithelium (trophectoderm) of the preimplantation conceptus, has been implicated as the antiluteolytic agent in sheep and cattle. IFN-alpha therapy during this critical period can also improve pregnancy success in sheep. It remains unclear, however, whether the trophoblast IFN have specialized biological properties or whether they are unique merely in the timing, magnitude and site of their expression.
为了存活下来，发育中的孕体必须中断母体正常的卵巢周期，并延长黄体产生孕酮的时间。一种特殊的1型干扰素（IFN），在结构上与IFN-α分子相关，由植入前孕体的第一层上皮（滋养外胚层）大量产生，仅持续几天，已被认为是绵羊和牛的抗黄体溶解因子。在此关键时期进行IFN-α治疗也可提高绵羊的妊娠成功率。然而，尚不清楚滋养层IFN是否具有特殊的生物学特性，或者它们仅仅在表达的时间、幅度和部位上是独特的。
