Saito S, Saito M, Motoyoshi K, Ichijo M
Department of Obstetrics and Gynecology, Nara Medical University, Japan.
Biochem Biophys Res Commun. 1991 Aug 15;178(3):1099-104. doi: 10.1016/0006-291x(91)91005-w.
Human macrophage colony-stimulating factor (hM-CSF) concentration-dependently enhanced the secretion of human chorionic gonadotropin (hCG) by primary cultured human cytotrophoblastic cells and a human placental cell line, 3A-SubE (tPA30-1). Since this effect appeared 12 hours after the addition of hM-CSF and disappeared when protein synthesis was inhibited, it was surmised that hCG synthesis was enhanced by hM-CSF. When anti fms (hM-CSF receptor) antibody was added, hCG secretion by cultured human cytotrophoblasts in early pregnancy markedly decreased. These findings demonstrate that hM-CSF acts on the chorionic villous cells and promotes hCG synthesis by these cells.
人巨噬细胞集落刺激因子（hM-CSF）以浓度依赖的方式增强了原代培养的人细胞滋养层细胞和人胎盘细胞系3A-SubE（tPA30-1）分泌人绒毛膜促性腺激素（hCG）的能力。由于这种作用在添加hM-CSF后12小时出现，并且在蛋白质合成受到抑制时消失，因此推测hM-CSF增强了hCG的合成。当加入抗fms（hM-CSF受体）抗体时，早孕时培养的人细胞滋养层细胞的hCG分泌明显减少。这些发现表明，hM-CSF作用于绒毛膜绒毛细胞并促进这些细胞合成hCG。
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