通过突变实现从HIV-1 Rev到HTLV-1 Rex的功能转换。

Functional conversion from HIV-1 Rev to HTLV-1 Rex by mutation.

作者信息

Kubota S, Nosaka T, Furuta R, Maki M, Hatanaka M

机构信息

Institute for Virus Research, Kyoto University, Japan.

出版信息

Biochem Biophys Res Commun. 1991 Aug 15;178(3):1226-32. doi: 10.1016/0006-291x(91)91024-7.

DOI:10.1016/0006-291x(91)91024-7

Abstract

A nucleolar localizing rev gene mutant M10 of human immunodeficiency virus type 1 (HIV-1) lost a Rev function completely, instead, gained a Rex activity of human T cell leukemia virus type 1 (HTLV-1). The obtained compatibility between Rev M10 and Rex with their own nucleolar targeting signal (NOS) suggests a common molecular mechanism of their post-transcriptional regulation, despite no sequence similarities of both proteins and their responsive RNA elements, respectively.

摘要

人类免疫缺陷病毒1型（HIV-1）的一种核仁定位的Rev基因突变体M10完全丧失了Rev功能，相反，却获得了人类T细胞白血病病毒1型（HTLV-1）的Rex活性。尽管Rev M10和Rex这两种蛋白质及其相应的RNA元件在序列上没有相似性，但它们与自身核仁靶向信号（NOS）之间获得的兼容性表明了它们转录后调控的共同分子机制。

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引用本文的文献

1

Inhibition of human immunodeficiency virus type 1 Rev function by a Rev mutant which interferes with nuclear/nucleolar localization of Rev.

J Virol. 1992 Apr;66(4):2510-3. doi: 10.1128/JVI.66.4.2510-2513.1992.

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