亚细胞Sox11分布模式可识别套细胞淋巴瘤亚群：与总生存期的相关性
The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival.
作者信息
Wang Xiao, Asplund A Charlotta, Porwit Anna, Flygare Jenny, Smith C I Edvard, Christensson Birger, Sander Birgitta
机构信息
Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden.
出版信息
Br J Haematol. 2008 Oct;143(2):248-52. doi: 10.1111/j.1365-2141.2008.07329.x. Epub 2008 Aug 20.
Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.
基因表达分析显示，神经元转录因子SOX11在套细胞淋巴瘤（MCL）中高表达。与滤泡性淋巴瘤、小淋巴细胞淋巴瘤和反应性淋巴组织不同，大多数检测的MCL（48/53例患者）在细胞核中表达SOX11蛋白。因此，细胞核SOX11表达代表了一部分MCL的新肿瘤标志物。然而，5/53例MCL病例仅在细胞质中表达SOX11；与细胞核表达SOX11的MCL患者相比，这些MCL患者的生存期较短。这些结果表明，SOX11表达可作为MCL中的一种新诊断标志物，可能与MCL的临床和生物学行为相关。
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